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Everyone can react to side effects differently. Some can be managed by preparing proactively with your health care team. It all comes down to planning, monitoring, and managing.
At the first sign of side effects, you and your doctor can take action. To help you develop a proactive management plan, below are some suggestions that your doctor may offer for managing some of the side effects of PIQRAY.
Because rash, diarrhea or colitis, and hyperglycemia can be serious yet common side effects of taking PIQRAY, it's important to understand how to manage these conditions so you can be ready. Watch the video below for helpful tips and information.
Hyperglycemia can appear within a median time of 15 days. At the earliest indication of high blood sugar levels, be sure to talk to your doctor and review the helpful information below.
Your doctor will monitor your blood sugar levels before starting and while taking PIQRAY. Your doctor may also have you monitor your blood sugar levels at home, which you should do in the morning, before eating or drinking. Though hyperglycemia is different from diabetes, your doctor may monitor your blood sugar levels more often if you have a history of Type 2 diabetes. The chart below shows a recommended monitoring schedule.
*After starting treatment, fasting glucose (FPG or fasting blood glucose) can be monitored
Signs of high blood sugar include:
Contact your doctor immediately if you experience any signs and symptoms of hyperglycemia. Your doctor may require dose interruption, reduction, or discontinuation based on the severity of hyperglycemia.
It’s important to note that in a clinical study, 87% of patients* with hyperglycemia were able to manage it with anti-hyperglycemic medication. In nearly all patients (96%)†, elevated blood sugar returned to pre-treatment levels after stopping treatment with PIQRAY.
*Of the 187 patients with hyperglycemia, 163 were managed with anti-hyperglycemic medication.
†Of the 54 patients with elevated blood sugar levels, 52 had levels that returned to baseline after discontinuing PIQRAY.
If you experience hyperglycemia, your doctor may prescribe a medication (such as metformin), along with suggested lifestyle changes, and may require dose interruption, reduction, or discontinuation based on the severity of hyperglycemia. Always talk to your doctor before making any changes to your diet or exercise routine.
Diarrhea is common with PIQRAY and may be severe. Follow your health care provider’s instructions for how to manage diarrhea.
Diarrhea and colitis are serious side effects of PIQRAY. Notify your doctor immediately if you develop diarrhea, stomach-area (abdominal) pain or see mucus or blood in your stool while taking PIQRAY. Your doctor may suggest that you drink more fluids or have an antidiarrheal medicine on hand to help manage your diarrhea. For colitis, your doctor may tell you to drink more fluids or take an additional treatment, such as enteric-acting and/or systemic steroids. Use these medicines only as directed by your doctor.
Talk to your doctor if antidiarrheal medicine does not help with your diarrhea. If you have diarrhea or colitis, your doctor may decrease your dose, have you take a break from treatment, or tell you to completely stop taking PIQRAY.
Diarrhea is a disorder characterized by more frequent and/or loose or watery bowel movements. Talk to your doctor as soon as you begin experiencing symptoms of diarrhea or colitis.
Watching what you eat and drink can help:
Talk to your doctor before making any changes to your diet.
Rash is one of the most common side effects of PIQRAY when used with fulvestrant, and can appear within 2 weeks. Your doctor may require dose interruption, reduction, or discontinuation based on the severity of rash.
Ask your doctor for clarification on any medication you're not familiar with.
Before a rash appears: Your doctor may prescribe an antihistamine to help reduce the chances of a rash developing. Taking antihistamines before a rash appears may decrease the chances of rash and severity of rash, based on the clinical trial.
If a rash does occur: Your doctor may prescribe one or more of the following types of medication (shown below) to help with symptoms, depending on their severity.
Topical corticosteroids: Creams applied directly to the skin that may reduce swelling and redness
Oral antihistamines: Medicines taken by mouth that may relieve itching
Systemic corticosteroids:Medicines taken by mouth or injection that may reduce swelling
Ask your doctor for clarification on any medication you're not familiar with.
Tell your doctor or seek medical help right away if you get severe rash or rash that keeps getting worse, reddened skin, flu-like symptoms, blistering of the lips, eyes or mouth, blisters on the skin or skin peeling, with or without fever. Depending on the severity, they may prescribe a stronger medication, interrupt treatment, or reduce your dose of PIQRAY.
Here are some tips for care of a rash at home: