Tips for managing potential side effects
Below are some suggestions that your doctor may offer for managing some of the side effects of PIQRAY. Always talk to your doctor before making any changes to your diet or exercise routine.
Understanding high blood sugar (hyperglycemia)
High blood sugar is common with PIQRAY, and can be severe. It’s important to understand the difference between hyperglycemia and diabetes.
- Hyperglycemia is high blood sugar due to any cause, and also a characteristic of diabetes.
- Type 1 Diabetes is a condition where your body stops making the insulin it needs to allow blood sugar to enter the cells of the body.
- Type 2 Diabetes is a condition where your body either doesn't make enough insulin or is unable to use it correctly.
The safety of PIQRAY in patients with Type 1 and uncontrolled Type 2 diabetes has not been established. If you have a history of diabetes, talk to your doctor about how that could affect your experience with PIQRAY.
In general, hyperglycemia that may be caused by PIQRAY is not diabetes.
If you experience hyperglycemia while taking PIQRAY, remember:
If you experience hyperglycemia, your doctor may prescribe a medication (such as metformin), along with suggested lifestyle changes, and may require dose interruption, reduction, or discontinuation based on the severity of hyperglycemia. Always talk to your doctor before making any changes to your diet or exercise routine.
Monitoring blood sugar
Your doctor will monitor your blood sugar levels before starting and while taking PIQRAY. Your doctor may also have you monitor your blood sugar levels at home, which you should do in the morning, before eating or drinking. Your doctor may monitor your blood sugar levels more often if you have a history of Type 2 diabetes. The chart below shows a recommended monitoring schedule.
Signs of high blood sugar include:
- Excessive thirst
- Urinating more often than usual or having a higher amount of urine than normal
- Dry mouth
- Increased appetite with weight loss
Contact your doctor immediately if you experience any signs and symptoms of hyperglycemia. Your doctor may require dose interruption, reduction, or discontinuation based on the severity of hyperglycemia.
Tips for managing diarrhea
Diarrhea is common with PIQRAY, and can be severe. Follow your health care provider’s instructions for how to manage diarrhea.
Help manage diarrhea by watching what you eat and drink
- Diarrhea can cause you to lose more fluid than you’re taking in, so it’s important to stay hydrated.
- Drink at least 8 glasses of clear liquids per day (such as water, broth, or sports drinks).
- Eat frequent, small meals and bland, easily digestible foods.
- Try the BRAT Diet: Bananas, Rice, Applesauce, and Toast.
- Avoid spicy and/or greasy foods, alcohol, coffee, tea, and soda with caffeine.
- Avoid milk and dairy products.
- Eat food high in protein, such as chicken, turkey, eggs, and fish.
Talk to your doctor before making any changes to your diet.
Tips for managing a rash
Rash is one of the most common side effects of PIQRAY when used with fulvestrant, and can appear within 2 weeks. Your doctor may require dose interruption, reduction, or discontinuation based on the severity of rash.
Ask your doctor about starting antihistamines and PIQRAY at the same time.
Before a rash appears: Your doctor may prescribe an antihisthamine to help reduce the chances of a rash developing. Taking antihistamines before a rash appears may decrease the chances of rash and severity of rash, based on the clinical trial.
If a rash does occur: Your doctor may prescribe one or more of the following types of medication (shown below) to help with symptoms, depending on their severity.
Ask your doctor for clarification on any medication you're not familiar with.
Taking care of a rash at home:
- Wear loose clothing.
- When outside, wear sunscreen or long sleeves and pants.
- Take cool or lukewarm showers.
- Use mild soap and unscented detergent.
- Gently pat your skin dry after bathing.