How to Take PIQRAY

PIQRAY® (alpelisib) tablets + fulvestrant

How to Take PIQRAY

PIQRAY is a once-daily oral tablet that is prescribed with fulvestrant, which is an injectable hormone therapy administered by your health care provider. It is important to always follow your doctor's directions on how to take PIQRAY.

Recommended Dosing

The recommended dose of PIQRAY is 300 mg (two 150-mg film-coated tablets) taken orally, once daily, with food. When given with PIQRAY, the recommended dose of fulvestrant is 500 mg administered on days 1, 15, and 29, and once monthly thereafter. Ask your doctor for additional dosing information for fulvestrant.


PIQRAY® (alpelisib) + fulvestrant dosing schedule

The PIQRAY blister pack is designed to help you stay on track with treatment.

PIQRAY blister pack PIQRAY blister pack

Dosing Instructions

PIQRAY dosing instructions PIQRAY dosing instructions
  • Take PIQRAY exactly as your health care provider tells you.
  • Do not change your dose or stop taking PIQRAY unless your health care provider tells you.
  • Take PIQRAY 1 time each day, at about the same time each day.
  • Take PIQRAY with food.
  • Swallow PIQRAY tablets whole. Do not chew, crush or split the tablets.
  • Do not take any PIQRAY tablets that are broken, cracked, or that look damaged.
  • If you miss a dose of PIQRAY, you may still take it with food up to 9 hours after the time you usually take it. If it has been more than 9 hours after you usually take your dose, skip the dose for that day. The next day, take the dose at your usual time. Do not take 2 doses to make up for a missed dose.
  • If you vomit after taking a dose of PIQRAY, do not take another dose on that day. Take your next dose at your usual time.
  • If you take too much PIQRAY, call your health care provider or go to the nearest hospital emergency room right away.