Understanding mBC

HR+, HER2- Metastatic Breast Cancer

About Metastatic Breast Cancer (mBC)

The stages of breast cancer range from 0-4. When breast cancer has progressed to stage 3 or 4, it’s considered advanced breast cancer.

Stage 3 breast cancer is when the cancer has spread beyond the breast and into nearby lymph nodes and muscles, but it has not yet spread to distant sites throughout the body.

Stage 4 breast cancer (also referred to as metastatic breast cancer, or mBC) is when cancer that began in the breast spreads to other parts of the body. Even when breast cancer is found elsewhere in the body, it’s still breast cancer, and should not be considered as any other type of cancer. Breast cancer can spread to any part of the body, but it most commonly metastasizes in the bones, lungs, liver, or brain.

mBC Statistics

Metastatic breast cancer statistics Metastatic breast cancer statistics

Knowing More About Your mBC

Understanding the specifics of your mBC can help your doctor determine the treatment approach that might be right for you.


Sometimes mutations (or abnormalities) in genes can contribute to the spread of cancer. In HR+, HER2- breast cancer, the most common mutation is PIK3CA, which has been linked to cancer growth.


An abnormal PIK3CA gene can create proteins that cause cancer cells to grow and spread. Patients with a PIK3CA mutation have the option of taking a therapy that specifically addresses this mutation. PIQRAY® (alpelisib) tablets work by inhibiting the action of those proteins to help treat HR+, HER2- mBC. PIQRAY can also affect healthy cells.


Although PIQRAY, in combination with fulvestrant, has been studied in postmenopausal women, and men, with HR+, HER2- mBC with an abnormal PIK3CA gene, who progressed on or after hormone therapy, how PIQRAY works has only been demonstrated in laboratory studies.


See how PIQRAY may help.

Most common metastatic breast cancer subtype and mutation Most common metastatic breast cancer subtype and mutation