Understanding mBC

HR+, HER2- Metastatic Breast Cancer

I didn’t choose mBC. But I did PIQ Clarity by learning everything I can

About metastatic breast cancer (mBC)

The stages of breast cancer range from 0-4. When breast cancer has progressed to stage 3 or 4, it’s considered advanced breast cancer. HR+, HER2- is the most common type of breast cancer. In this type, hormones help the cancer to grow.

Stage 3 breast cancer is when the cancer has spread beyond the breast and into nearby lymph nodes and muscles, but it has not yet spread to distant sites throughout the body.

Stage 4 breast cancer (also referred to as metastatic breast cancer, or mBC) is when cancer that began in the breast spreads to other parts of the body. Even when breast cancer is found elsewhere in the body, it’s still breast cancer, and should not be considered as any other type of cancer. Breast cancer can spread to any part of the body, but it most commonly metastasizes in the bones, lungs, liver, or brain.

mBC statistics

breast cancer statistics

Knowing more about your mBC

Knowing what type of mBC you have and what may cause your cancer to grow is important. There are also certain mutations that could impact your cancer and treatment options, such as if you have the PIK3CA mutation. Understanding the specifics of your mBC can help your doctor determine the right treatment approach for you.  


Sometimes mutations (or abnormalities) in genes can contribute to the spread of cancer. In HR+, HER2- breast cancer, the most common mutation is a PIK3CA mutation, which has been linked to cancer growth.


An abnormal PIK3CA gene can create proteins that cause cancer cells to grow and spread. Patients who have progressed on hormone therapy and have a PIK3CA mutation have the option of taking a therapy that specifically addresses this mutation. PIQRAY works by inhibiting the action of those proteins to help treat HR+, HER2- mBC. PIQRAY can also affect healthy cells.


Although PIQRAY, in combination with fulvestrant, has been studied in postmenopausal women, and men, with HR+, HER2- mBC with an abnormal PIK3CA gene, who progressed on or after hormone therapy, how PIQRAY works has only been demonstrated in laboratory studies.


See how PIQRAY may help.

Most common metastatic breast cancer subtype and mutation