Understanding PIK3CA and  HR+, HER2- Metastatic Breast Cancer 

Knowing more about your metastatic breast cancer (mBC)

There are many factors that can help you find a metastatic breast cancer treatment. It is important to know your stage of disease, along with the specific type and mutation, as this information will help you better understand what may cause your cancer to grow. HR+, HER2- is the most common type of breast cancer. In this type, hormones help the cancer to grow. To learn more about the PIK3CA mutation in metastatic breast cancer, you can sign up for our email list.


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mBC can occur 5, 10, or even 15 years after an early-stage diagnosis.
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mBC can grow with the help of proteins, hormones, and sometimes mutations (or abnormalities) in certain genes, such as PIK3CA mutations.
I didn’t choose mBC. But I did PIQ Clarity by learning everything I can

PIK3CA mutations

Sometimes mutations (or abnormalities) in genes can contribute to the spread of cancer. In HR+, HER2- breast cancer, the most common mutation is a PIK3CA mutation, which has been linked to cancer growth. Just as your HR and HER2 status inform your doctor whether certain proteins fuel your cancer, your PIK3CA mutation status tells your doctor whether a common gene mutation may be contributing to the growth of your cancer.

Biomarker testing is the first step to diagnosis


If you have the PIK3CA mutation and progressed on or after an endocrine therapy, PIQRAY may be right for your HR+, HER2- metastatic breast cancer treatment. Getting tested for the PIK3CA mutation is the first step. Ask your doctor about testing.

Who has metastatic breast cancer?




About 155,000 people in the United States are currently living with metastatic breast cancer.






About 70% of all people with breast cancer are HR+, HER2-.







About 40% of all people with HR+, HER2- mBC have a PIK3CA mutation.

Living with metastatic breast cancer (mBC)

The stages of breast cancer range from 0-4. When breast cancer has progressed to stage 3 or 4, it’s considered advanced breast cancer. Explore the toggle to see the differences in stage 3 and 4.

Stage 3 breast cancer is when the cancer has spread beyond the breast and into nearby lymph nodes and muscles, but it has not yet spread to distant sites throughout the body.

Stage 4 breast cancer (also referred to as metastatic breast cancer, or mBC) is when cancer that began in the breast spreads to other parts of the body. Even when breast cancer is found elsewhere in the body, it’s still breast cancer, and should not be considered as any other type of cancer. Breast cancer can spread to any part of the body, but it most commonly metastasizes in the bones, lungs, liver, or brain.


Talk to your doctor about PIQRAY.