PIK3CA in mBC

Understanding PIK3CA and  HR+, HER2- Metastatic Breast Cancer 

I didn’t choose mBC. But I did PIQ Clarity by learning everything I can

Knowing more about your metastatic breast cancer (mBC)

There are many factors that can help you find a metastatic breast cancer treatment. It is important to know your stage of disease, along with the specific type and mutation, as this information will help you better understand what may cause your cancer to grow. HR+, HER2- is the most common type of breast cancer. In this type, hormones help the cancer to grow.

PIK3CA mutations

Sometimes mutations (or abnormalities) in genes can contribute to the spread of cancer. In HR+, HER2- breast cancer, the most common mutation is a PIK3CA mutation, which has been linked to cancer growth. Just as your HR and HER2 status inform your doctor whether certain proteins fuel your cancer, your PIK3CA mutation status tells your doctor whether a common gene mutation may be contributing to the growth of your cancer.

Biomarker testing is the first step to diagnosis

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If you have the PIK3CA mutation and progressed on or after an endocrine therapy, PIQRAY may be right for your HR+, HER2- metastatic breast cancer treatment. Getting tested for the PIK3CA mutation is the first step. Ask your doctor about testing.

How common are PIK3CA mutations?

40prcnt Statistic 

About 40% of all people with HR+, HER2- metastatic breast cancer have a PIK3CA mutation.

If you test positive for a PIK3CA mutation and have progressed on or after hormone therapy, you and your doctor can consider PIQRAY® (alpelisib) tablets.

Living with metastatic breast cancer (mBC)

The stages of breast cancer range from 0-4. When breast cancer has progressed to stage 3 or 4, it’s considered advanced breast cancer.

Stage 3 breast cancer is when the cancer has spread beyond the breast and into nearby lymph nodes and muscles, but it has not yet spread to distant sites throughout the body.

Stage 4 breast cancer (also referred to as metastatic breast cancer, or mBC) is when cancer that began in the breast spreads to other parts of the body. Even when breast cancer is found elsewhere in the body, it’s still breast cancer, and should not be considered as any other type of cancer. Breast cancer can spread to any part of the body, but it most commonly metastasizes in the bones, lungs, liver, or brain.

 

Talk to your doctor about PIQRAY for Stage 4 breast cancer treatment.

Who has metastatic breast cancer?

155k

 

 

About 155,000 people in the United States are currently living with metastatic breast cancer.

 

 

155k

 

 

About 70% of all people with breast cancer are HR+, HER2-.

 

 

 

155k

 

 

About 40% of all people with HR+, HER2- mBC have a PIK3CA mutation.