Testing & Diagnosis

Finding PIK3CA Mutations in HR+, HER2- Metastatic Breast Cancer

PIK3CA mutation testing

There is likely no shortage of tests in your life right now. However, getting an in-depth look at your HR+, HER2- metastatic breast cancer (mBC) and whether you have a specific mutation will help you and your doctor determine the right treatment for you. To determine your PIK3CA mutation status, your doctor will test your breast cancer for an abnormal PIK3CA gene.


How PIK3CA mutation testing works:

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Who can request it: PIK3CA mutations can only be detected through a specific genomic test ordered by your doctor.

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How to request it: Even if you’ve had genetic testing done before, you’ll need to ask specifically for a PIK3CA mutation test.

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How the test is performed: PIK3CA mutations can be detected in tissue or plasma specimens.1 Your doctor will send a tissue or blood sample (to get a plasma specimen). If you’ve had a biopsy done before, ask your doctor if your tissue is still viable for PIK3CA gene mutation testing. If you do not, your doctor may start with a blood test. If no mutation is found in the plasma specimen, ask your doctor to test your tissue to confirm.

1 Piqray [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2020.

Who has metastatic breast cancer?

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It is estimated that 155,000 people in the United States are currently living with mBC.
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mBC can occur 5, 10, or even 15 years after an early-stage diagnosis.
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mBC can grow with the help of proteins, hormones, and sometimes mutations (or abnormalities) in certain genes, such as PIK3CA mutations.